Endocrine Abstracts

Introduction: Anaplastic thyroid carcinoma (ATC) is the most aggressive and invasive histological type of thyroid carcinomas. Frequently, upon diagnosis obstructive symptoms and loco-regional metastasis have already occurred. Presence of distant metastasis in the skeletal muscle in ATC is rare; and there are less than five documented cases reported worldwide.Case: A 68-year-old Filipino Male, presents with two-month history of pain on the right thigh. He...

Introduction: The repercussions of long-term exposure to low level mixtures of endocrine disrupting compounds (EDCs) which are present, ubiquitously, in the environment are not well understood. Heat-treated sewage sludge, an EDC-rich product used as fertiliser, has been shown to compromise testicular and ovarian development. However, to date, there has been limited investigation in exposed animals of the adrenal glands, the steroid hormone products of which play key roles in f...

Introduction: The treatment of hyperthyroidism is complex. Radio-iodine administration remains the definitive option despite debate regarding optimum dosage and strategy.Method: Thyroid status in all patients receiving first dose radio-iodine over a 5 year period was reviewed at 3, 6, 12 and (most at) 24 months. Radio-iodine doses were individualised depending on thyroid gland size, co-morbidities and patient choice. The objective was euthyroidism with h...

Background: Patients with complete androgen insensitivity syndrome (CAIS) who undergo gonadectomy have evidence of reduced bone mineral density (BMD) and perhaps, higher risk of fragility fractures. Because of this, hormonal replacement therapy (HRT), usually in the form of estrogen, is used as patients with CAIS have 46, XY genotypes having androgen receptor abnormalities making them resistant to the effects of androgen. Tibolone, a “selective tissue estrogenic activity...